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Because irbesartan isn't going to inhibit ACE, it does not affect the reaction to bradykinin; whether or not this has scientific relevance will not be acknowledged.
Signs and symptoms of overdose consist of hypotension and tachycardia or bradycardia. Terlipressin could be provided to deal with hypotension and tachycardia if traditional vasopressors fail to control blood pressure.
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Irbesartan is a certain aggressive antagonist of AT1 receptors with a much higher affinity (over 8500-fold) for the AT1 receptor than for your AT2 receptor, and no agonist action.
Blockade of your AT1 receptor eliminates the unfavorable feed-back of angiotensin II on renin secretion, even so the resulting amplified plasma renin action and circulating angiotensin II do not defeat the effects of irbesartan on hypertension.
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